| ncRNA name | CREB shRNA |
| ncRNA Category | shRNA |
| Disease name | uveal melanoma (UM) |
| Species | Homo sapiens |
| Tissues/Cell_line | UM cell lines OMM2.5 and Mel270 |
| Methods | shRNA knockdown, immunofluorescence, qPCR, Western blot, luciferase reporter assay, flow cytometry, cell viability assay |
| Expression pattern | associated |
| Functional description | We found that CREB knockdown increases the sensitivity of these cells to both DOX and DTIC in normoxia and more so in hypoxia as measured by cell survival and Caspase 3 activation. |
| PubMed ID | 29899845 |
| Year | 2018 |
| Title | A novel combinatorial treatment option for metastatic uveal melanoma. |
| Drug-related ncRNA | YES (doxorubicin (DOX), fotemustine or dacarbazine (DTIC)) |
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